Bungo Akiyoshi - Evolutionary cell biology of chromosome segregation

We want to reveal fundamental principles of chromosome segregation by studying an unconventional type of kinetochores that we discovered in African trypanosomes

Francis Barr - Mechanisms of human cell division & organelle identity

My research group addresses fundamental questions in cell division and cancer cell biology. We are particularly interested in how cells accurately segregate their chromosomes and divide to create new cells.

Neil Brockdorff - The Molecular Mechanism of X chromosome inactivation

Our long-term goal is to define the molecular mechanism of X chromosome inactivation, and through this to discover fundamental processes governing developmental gene regulation.

Alfredo Castello - RNA-binding proteins in health and disease

We are fascinated by the mechanisms employed by RNA-binding proteins (RBPs) to control gene expression at the post-transcriptional level. We employ cutting edge techniques to discover how RBPs dictate cell fate and what are the pathological consequences of their dysregulation.

Martin Cohn - Maintenance of genomic stability and DNA repair in humans

The Cohn group is uncovering mechanisms of DNA repair in humans, thereby understanding molecular processes leading to cancer.

 

Ilan Davis -The RNA Biology of Neural Stem Cell Development and Synaptic Plasticity

We are interested in understanding post-transcriptional regulation of gene expression and its role in brain development.

Andre Furger - Gene regulation in response to stress and disease progression

We investigate how eukaryotic cells change their gene expression programs in response to specific biotic and abiotic stresses and during disease progression

Ian Gibbs-Seymour - Genome stability and its regulatory signalling mechanisms

We are interested in understanding the mechanisms of DNA repair in mammalian cells.

Lars E.T. Jansen - Mechanisms of chromatin inheritance

How is chromatin inherited, how it copied by self-templated duplications and how are these processes synchronised with cell division

Rob Klose - Epigenetic regulation of chromatin function

We are discovering how CpG island elements in mammalian genomes use chromatin-based and epigenetic mechanisms to regulate gene expression in development and disease.

 

Nick Lakin - Detection, Signalling and Repair of DNA Damage

Our goal is to understand the mechanistic basis of how cells maintain genome integrity through DNA repair with the long term vision of exploiting this knowledge to treat a variety of pathologies, including cancer

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Jane Mellor - Chromatin remodeling and gene regulation in simple eukaryotes

We study all aspects of gene expression from transcription to translation, with a current focus on understanding how higher order structures in the chromatin impact on nuclear and cytoplasmic events and thus phenotype.

Kim Nasmyth - SMC complex function in chromosome condensation, segregation and regulation of gene expression

We aim to understand the mechanisms of co-entrapment of sister DNAs within the cohesin ring and loop extrusion by SMC-Kleisin complexes

Tim Nott - Compartmentalisation via liquid-liquid phase separation in cells

Our research is aimed at understanding sub-cellular organisation, and in particular how and why cells perform certain biochemical reactions inside membraneless organelles.

Catherine Pears - Cell Signalling

We aim to understand the mechanisms to regulate and maintain developmental gene expression during differentiation of different cell types from stem cells.  

Lidia Vasilieva - Transcriptional and post-transcriptional regulation of gene expression in eukaryotes

We would like to understand how eukaryotic cells control levels of individual mRNAs.

Matthew Whitby - Genetic recombination and DNA repair in eukaryotes

We are investigating the crucial role that homologous recombination plays in the repair and replication of DNA.

Alison Woollard - Molecular mechanisms controlling cell fate determination and cell proliferation in development

We are interested in fundamental questions in development and ageing, including the molecular mechanisms by which cells become different from one another, how tissues remodel, and how the developmental programme contributes to ageing.

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Dragana Ahel - Mechanisms of genome stability

Our lab is interested in discovering the mechanisms that maintain genome stability.

 

Ivan Ahel - DNA repair mechanisms and human disease

Our goal is to understand the role of PARPs and ADP-ribosylation signalling in regulation of genome stability.

Fumiko Esashi - Genome Stability and Cell Cycle

We study how proliferating human cells safeguard their genomic DNA against various stress coming from the environment and from normal processes of cell growth.

Natalia Gromak - Molecular mechanisms of neurodegenerative diseases

Our lab is interested in understanding the molecular biology of unusual RNA/DNA structures and their contribution to basic cellular processes and human disease.

Ulrike Gruneberg - Mitotic progression

My research group focuses on understanding the mechanics and regulation of cell division and chromosome segregation in human cells.

 

Shona Murphy -The CTD of RNA polymerase II and elongation checkpoints

We study the link between RNA processing and transcription by RNA polymerase II.

Nicholas Proudfoot - Gene punctuation: transcriptional termination in eukaryotes

We study molecular mechanisms that define transcription units in mammalian genomes.

Jordan Raff - Molecular dissection of centrioles and cilia

We study centrioles, centrosomes and cilia as models to understand the basic principles of organelle function and biogenesis.

Elizabeth Robertson - Transcriptional regulators of mammalian development

We are interested in how signalling pathways and transcriptional regulators govern cell fate decisions in developing mammalian embryo.

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Paul Riley - Embryonic development of the heart

Our long term goal is to understand how developmental processes within the forming heart can be harnessed to optimise tissue repair and regeneration after adult heart injury.

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Shankar Srinivas -  Morphogenesis of the early mammalian embryo

We study how embryonic form arises during development, with a particular focus on the origin of the head-tail axis and the formation of the beating heart.

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Clive Wilson - Cell-cell communication and exosomes in development

We study the mechanisms by which cells communicate with each other in development, adults and disease, focusing particularly on complex signals involving vesicles and other multi-molecular complexes.

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Marella de Bruijn - Developmental Hematopoiesis

We are interested in gene regulation in the development of the hematopoietic/immune system in the embryo.

Tudor Fulga - Genome engineering and synthetic biology

We aim to decipher the logic of post-transcriptional gene regulation and to harness this knowledge to create synthetic systems that rewire or enhance naturally evolved cellular behaviours.

Doug Higgs - Gene Regulation

We study the principles by which fundamental genome regulatory elements (enhancers, promoters and boundary elements) interact to switch genes on and off during lineage fate decisions, differentiation and maturation throughout development.

Peter McHugh - DNA damage and repair

We aim to understand how repair of damaged DNA is controlled during chromosome duplication in order to improve the treatment of cancer and other human diseases'

Catherine Porcher - Molecular dissection of blood cell fate determination

We are interested in the transcriptional and epigenetic mechanisms underlying specification of the blood lineage from mesoderm and in modelling development of blood stem cells in vitro from pluripotent stem cells.

Tatjana Sauka-Spengler - Gene Regulatory Networks in Development and Disease

We use systems level epigenomic and transcriptional approaches at single-cell and population levels to decipher and reverse engineer gene regulatory networks in specific developmental cell types using zebrafish, chick, lamprey and human models.

Ross Chapman - Genome stability and DNA repair mechanisms in cancer and genome diversification 

We aim to define the molecular mechanisms that maintain the correct equilibrium between accurate and mutagenic DNA repair pathways, and understand why imbalances in this regulation result in cancer and human disease.