We want to reveal fundamental principles of chromosome segregation by studying an unconventional type of kinetochores that we discovered in African trypanosomes
My research group addresses fundamental questions in cell division and cancer cell biology. We are particularly interested in how cells accurately segregate their chromosomes and divide to create new cells.
Our long-term goal is to define the molecular mechanism of X chromosome inactivation, and through this to discover fundamental processes governing developmental gene regulation.
We are fascinated by the mechanisms employed by RNA-binding proteins (RBPs) to control gene expression at the post-transcriptional level. We employ cutting edge techniques to discover how RBPs dictate cell fate and what are the pathological consequences of their dysregulation.
We are interested in understanding post-transcriptional regulation of gene expression and its role in brain development.
We investigate how eukaryotic cells change their gene expression programs in response to specific biotic and abiotic stresses and during disease progression
We are discovering how CpG island elements in mammalian genomes use chromatin-based and epigenetic mechanisms to regulate gene expression in development and disease.
Our goal is to understand the mechanistic basis of how cells maintain genome integrity through DNA repair with the long term vision of exploiting this knowledge to treat a variety of pathologies, including cancer
Jane Mellor - Chromatin remodeling and gene regulation in simple eukaryotes
We study all aspects of gene expression from transcription to translation, with a current focus on understanding how higher order structures in the chromatin impact on nuclear and cytoplasmic events and thus phenotype.
Kim Nasmyth - SMC complex function in chromosome condensation, segregation and regulation of gene expression
We aim to understand the mechanisms of co-entrapment of sister DNAs within the cohesin ring and loop extrusion by SMC-Kleisin complexes
Our research is aimed at understanding sub-cellular organisation, and in particular how and why cells perform certain biochemical reactions inside membraneless organelles.
Alison Woollard - Molecular mechanisms controlling cell fate determination and cell proliferation in development
We are interested in fundamental questions in development and ageing, including the molecular mechanisms by which cells become different from one another, how tissues remodel, and how the developmental programme contributes to ageing.
Our lab is interested in understanding the molecular biology of unusual RNA/DNA structures and their contribution to basic cellular processes and human disease.
We are interested in how signalling pathways and transcriptional regulators govern cell fate decisions in developing mammalian embryo.
Our long term goal is to understand how developmental processes within the forming heart can be harnessed to optimise tissue repair and regeneration after adult heart injury.
Shankar Srinivas - Morphogenesis of the early mammalian embryo
We study how embryonic form arises during development, with a particular focus on the origin of the head-tail axis and the formation of the beating heart.
Clive Wilson - Cell-cell communication and exosomes in development
We study the mechanisms by which cells communicate with each other in development, adults and disease, focusing particularly on complex signals involving vesicles and other multi-molecular complexes.
We aim to decipher the logic of post-transcriptional gene regulation and to harness this knowledge to create synthetic systems that rewire or enhance naturally evolved cellular behaviours.
Catherine Porcher - Molecular dissection of blood cell fate determination
We are interested in the transcriptional and epigenetic mechanisms underlying specification of the blood lineage from mesoderm and in modelling development of blood stem cells in vitro from pluripotent stem cells.
Tatjana Sauka-Spengler - Gene Regulatory Networks in Development and Disease
We use systems level epigenomic and transcriptional approaches at single-cell and population levels to decipher and reverse engineer gene regulatory networks in specific developmental cell types using zebrafish, chick, lamprey and human models.
We aim to define the molecular mechanisms that maintain the correct equilibrium between accurate and mutagenic DNA repair pathways, and understand why imbalances in this regulation result in cancer and human disease.